Activation of Aurora A kinase increases YAP stability via blockage of autophagy
Identifieur interne : 000B15 ( Main/Exploration ); précédent : 000B14; suivant : 000B16Activation of Aurora A kinase increases YAP stability via blockage of autophagy
Auteurs : Peng Wang [République populaire de Chine] ; Ying Gong [République populaire de Chine] ; Tao Guo [République populaire de Chine] ; Man Li [République populaire de Chine] ; Lei Fang [République populaire de Chine] ; Shengchen Yin [République populaire de Chine] ; Muhammad Kamran [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Jie Xu [République populaire de Chine] ; Lingzhi Xu [République populaire de Chine] ; Fei Peng [République populaire de Chine] ; Xiaoyuan Xue [République populaire de Chine] ; Mengying Yang [République populaire de Chine] ; Mie-Chie Hung [États-Unis] ; Eric W.-F. Lam ; Chundong Gu [République populaire de Chine] ; Chunli Wang [République populaire de Chine] ; Qimin Zhan [République populaire de Chine] ; Quentin Liu [République populaire de Chine]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2019.
Abstract
Transcription cofactor Yes-associated protein (YAP) plays an important role in cancer progression. Here, we found that Aurora A kinase expression was positively correlated with YAP in lung cancer. Aurora A depletion suppresses lung cancer cell colony formation, which could be reversed by YAP ectopic overexpression. In addition, activation of Aurora A increases YAP protein abundance through maintaining its protein stability. Consistently, the transcriptional activity of YAP is increased upon Aurora A activation. We further showed that shAURKA suppressed YAP expression in the absence of Lats1/2, indicating that Aurora A regulates YAP independently of Hippo pathway. Instead, Aurora A induced blockage of autophagy to up-regulate YAP expression. Collectively, our findings provide insights into regulatory mechanisms of YAP expression in lung cancer development.
Url:
DOI: 10.1038/s41419-019-1664-4
PubMed: 31160567
PubMed Central: 6547697
Affiliations:
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sortKey="Liu, Quentin" sort="Liu, Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31160567</idno><idno type="pmc">6547697</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547697</idno><idno type="RBID">PMC:6547697</idno><idno type="doi">10.1038/s41419-019-1664-4</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000058</idno><idno type="wicri:explorRef" 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last="Yin">Shengchen Yin</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>The First Affiliated Hospital,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Kamran, Muhammad" sort="Kamran, Muhammad" uniqKey="Kamran M" first="Muhammad" last="Kamran">Muhammad Kamran</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>The First Affiliated Hospital,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Jie" sort="Xu, Jie" uniqKey="Xu J" first="Jie" last="Xu">Jie Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Lingzhi" sort="Xu, Lingzhi" uniqKey="Xu L" first="Lingzhi" last="Xu">Lingzhi Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>The Second Affiliated Hospital,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Fei" sort="Peng, Fei" uniqKey="Peng F" first="Fei" last="Peng">Fei Peng</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Xue, Xiaoyuan" sort="Xue, Xiaoyuan" uniqKey="Xue X" first="Xiaoyuan" last="Xue">Xiaoyuan Xue</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Mengying" sort="Yang, Mengying" uniqKey="Yang M" first="Mengying" last="Yang">Mengying Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Hung, Mie Chie" sort="Hung, Mie Chie" uniqKey="Hung M" first="Mie-Chie" last="Hung">Mie-Chie Hung</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson cancer center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Lam, Eric W F" sort="Lam, Eric W F" uniqKey="Lam E" first="Eric W.-F." last="Lam">Eric W.-F. Lam</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id><institution-id institution-id-type="GRID">grid.7445.2</institution-id><institution>Department of Surgery and Cancer,</institution><institution>Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM),</institution></institution-wrap>Du Cane Road, London, W12 0NN UK</nlm:aff><wicri:noCountry code="subfield">W12 0NN UK</wicri:noCountry></affiliation></author><author><name sortKey="Gu, Chundong" sort="Gu, Chundong" uniqKey="Gu C" first="Chundong" last="Gu">Chundong Gu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>The First Affiliated Hospital,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Chunli" sort="Wang, Chunli" uniqKey="Wang C" first="Chunli" last="Wang">Chunli Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Zhan, Qimin" sort="Zhan, Qimin" uniqKey="Zhan Q" first="Qimin" last="Zhan">Qimin Zhan</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0027 0586</institution-id><institution-id institution-id-type="GRID">grid.412474.0</institution-id><institution>Laboratory of Molecular Oncology,</institution><institution>Peking University Cancer Hospital & Institute,</institution></institution-wrap>Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Quentin" sort="Liu, Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9558 1426</institution-id><institution-id institution-id-type="GRID">grid.411971.b</institution-id><institution>Institute of Cancer Stem Cell,</institution><institution>Dalian Medical University,</institution></institution-wrap>Dalian, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Death & Disease</title><idno type="eISSN">2041-4889</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Transcription cofactor Yes-associated protein (YAP) plays an important role in cancer progression. Here, we found that Aurora A kinase expression was positively correlated with YAP in lung cancer. Aurora A depletion suppresses lung cancer cell colony formation, which could be reversed by YAP ectopic overexpression. In addition, activation of Aurora A increases YAP protein abundance through maintaining its protein stability. Consistently, the transcriptional activity of YAP is increased upon Aurora A activation. We further showed that shAURKA suppressed YAP expression in the absence of Lats1/2, indicating that Aurora A regulates YAP independently of Hippo pathway. Instead, Aurora A induced blockage of autophagy to up-regulate YAP expression. Collectively, our findings provide insights into regulatory mechanisms of YAP expression in lung cancer development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pan, D" uniqKey="Pan D">D Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, Qy" uniqKey="Lei Q">QY Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, H" uniqKey="Oh H">H Oh</name></author><author><name sortKey="Irvine, Kd" uniqKey="Irvine K">KD Irvine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, F" uniqKey="Ren F">F Ren</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Fx" uniqKey="Yu F">FX Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basu, S" uniqKey="Basu S">S Basu</name></author><author><name sortKey="Totty, Nf" uniqKey="Totty N">NF Totty</name></author><author><name sortKey="Irwin, Ms" uniqKey="Irwin M">MS Irwin</name></author><author><name sortKey="Sudol, M" uniqKey="Sudol M">M Sudol</name></author><author><name sortKey="Downward, J" uniqKey="Downward J">J Downward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanai, F" uniqKey="Kanai F">F Kanai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author><author><name sortKey="Li, L" 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Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, M" uniqKey="Yan M">M Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zou, Z" uniqKey="Zou Z">Z Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Lz" uniqKey="Xu L">LZ Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author><author><name sortKey="Jaattela, M" uniqKey="Jaattela M">M Jaattela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, M" uniqKey="Yan M">M Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Necchi, A" uniqKey="Necchi A">A Necchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Brocklyn, Jr" uniqKey="Van Brocklyn J">JR Van Brocklyn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, F" uniqKey="Liu F">F Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moran, A" uniqKey="Moran A">A Moran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiller, Jh" uniqKey="Schiller J">JH Schiller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, N" uniqKey="Liang N">N Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruber, R" uniqKey="Gruber R">R Gruber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haemmerle, M" uniqKey="Haemmerle M">M Haemmerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name></author><author><name sortKey="Overholtzer, M" uniqKey="Overholtzer M">M Overholtzer</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Pm" uniqKey="Wong P">PM Wong</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Shi, R" uniqKey="Shi R">R Shi</name></author><author><name sortKey="Jiang, X" uniqKey="Jiang X">X Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tumaneng, K" uniqKey="Tumaneng K">K Tumaneng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu Chittenden, Y" uniqKey="Liu Chittenden Y">Y Liu-Chittenden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melichar, B" uniqKey="Melichar B">B Melichar</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Lam, Eric W F" sort="Lam, Eric W F" uniqKey="Lam E" first="Eric W.-F." last="Lam">Eric W.-F. Lam</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Peng" sort="Wang, Peng" uniqKey="Wang P" first="Peng" last="Wang">Peng Wang</name></noRegion><name sortKey="Fang, Lei" sort="Fang, Lei" uniqKey="Fang L" first="Lei" last="Fang">Lei Fang</name><name sortKey="Fang, Lei" sort="Fang, Lei" uniqKey="Fang L" first="Lei" last="Fang">Lei Fang</name><name sortKey="Gong, Ying" sort="Gong, Ying" uniqKey="Gong Y" first="Ying" last="Gong">Ying Gong</name><name sortKey="Gong, Ying" sort="Gong, Ying" uniqKey="Gong Y" first="Ying" last="Gong">Ying Gong</name><name sortKey="Gu, Chundong" sort="Gu, Chundong" uniqKey="Gu C" first="Chundong" last="Gu">Chundong Gu</name><name sortKey="Gu, Chundong" sort="Gu, Chundong" uniqKey="Gu C" first="Chundong" last="Gu">Chundong Gu</name><name sortKey="Guo, Tao" sort="Guo, Tao" uniqKey="Guo T" first="Tao" last="Guo">Tao Guo</name><name sortKey="Guo, Tao" sort="Guo, Tao" uniqKey="Guo T" first="Tao" last="Guo">Tao Guo</name><name sortKey="Kamran, Muhammad" sort="Kamran, Muhammad" uniqKey="Kamran M" first="Muhammad" last="Kamran">Muhammad Kamran</name><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><name sortKey="Liu, Quentin" sort="Liu, Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Peng, Fei" sort="Peng, Fei" uniqKey="Peng F" first="Fei" last="Peng">Fei Peng</name><name sortKey="Wang, Chunli" sort="Wang, Chunli" uniqKey="Wang C" first="Chunli" last="Wang">Chunli Wang</name><name sortKey="Wang, Peng" sort="Wang, Peng" uniqKey="Wang P" first="Peng" last="Wang">Peng Wang</name><name sortKey="Xu, Jie" sort="Xu, Jie" uniqKey="Xu J" first="Jie" last="Xu">Jie Xu</name><name sortKey="Xu, Lingzhi" sort="Xu, Lingzhi" uniqKey="Xu L" first="Lingzhi" last="Xu">Lingzhi Xu</name><name sortKey="Xue, Xiaoyuan" sort="Xue, Xiaoyuan" uniqKey="Xue X" first="Xiaoyuan" last="Xue">Xiaoyuan Xue</name><name sortKey="Yang, Mengying" sort="Yang, Mengying" uniqKey="Yang M" first="Mengying" last="Yang">Mengying Yang</name><name sortKey="Yin, Shengchen" sort="Yin, Shengchen" uniqKey="Yin S" first="Shengchen" last="Yin">Shengchen Yin</name><name sortKey="Zhan, Qimin" sort="Zhan, Qimin" uniqKey="Zhan Q" first="Qimin" last="Zhan">Qimin Zhan</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Hung, Mie Chie" sort="Hung, Mie Chie" uniqKey="Hung M" first="Mie-Chie" last="Hung">Mie-Chie Hung</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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